Polar opposites Jamie (Jake Gyllenhaal), a womanizing pharma salesman on the corporate fast track, and Maggie (Anne Hathaway), a mysterious free spirit, find themselves taken by surprise when they fall victim to life’s ultimate drug: love.
Maggie (Anne Hathaway) is an alluring free spirit who won't let anyone — or anything — tie her down. But she meets her match in Jamie (Jake Gyllenhaal), whose relentless and nearly infallible charm serve him well with the ladies and in the cutthroat world of pharmaceutical sales. Maggie and Jamie's evolving relationship takes them both by surprise, as they find themselves under the influence of the ultimate drug: love.